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Spotlight on Applied Research

Research Initiatives

Patterns of Care Study to Focus on HCC, CML, & Late-stage Breast Cancer

The National Cancer Institute's annual Patterns of Care/Quality of Care (POC/QOC) studies are Congressionally mandated and managed by the Applied Research Program (ARP)'s Health Services and Economics Branch (HSEB). The POC/QOC studies evaluate the diffusion of cancer therapies in community health care settings by randomly sampling patients diagnosed with specific cancers and registered in the Surveillance, Epidemiology and End Results (SEER) program. Through additional medical record abstraction and by querying treating physicians, the POC/QOC studies are better able to collect data on therapy (e.g., chemotherapy, hormonal therapy) and potential determinants of care (e.g., comorbidities, biomarkers) than use of SEER data alone.

The 2014 POC/QOC study will sample adults diagnosed in 2012 with hepatocellular cancer (HCC), chronic myelogenous leukemia (CML), or late-stage female breast cancer. In addition to assessing the use of site-specific chemotherapy agents, the study aims to assess:

  • HCC treatment patterns by comorbidities (e.g., obesity, hepatitis, cirrhosis) and clinical prognostic factors (e.g., Child-Pugh and Cancer of the Liver Italian Program [CLIP] scores);
  • CML treatment patterns by T315I mutation, which is a genetic marker of treatment resistance, and clinical markers (cytogenetic and molecular) of treatment response; and
  • late-stage breast cancer treatment patterns by obesity, method of detection, and whether the prescribed cycles of chemotherapy were completed. Additionally, the feasibility of conducting an "accelerated" POC/QOC study will be assessed; POC/QOC data will be matched to the incidence SEER submission, making the data more timely.

Last Modified: 11 Apr 2014