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Comparative Effectiveness Research

Comparative Effectiveness Research (CER) is the conduct and synthesis of systematic research comparing different interventions and strategies to prevent, diagnose, treat and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers about which interventions are most effective for which patients under specific circumstances.

The Applied Research Program conducts and supports a variety of CER efforts. For example, the following data resources are being used to investigate comparative effectiveness research questions:

The PROMIS initiative will enhance understanding of the physical and emotional consequences of experimental and standard cancer treatments on cancer patients.

The PRO-CTCAE is a patient-reported outcome (PRO) measurement tool. It profiles the frequency, severity, and interference with daily life of symptomatic toxicities experienced by patients on clinical trials. Treatment-related toxicity (safety and tolerability) is a fundamental outcome when drawing conclusions about therapeutic effectiveness, including comparative effectiveness.

Last Modified: 24 Sep 2014